《特質(zhì)焦慮對(duì)酒精依賴患者的抑制控制的影響：同時(shí)獲取ERPS和BOLD反應(yīng)2008已閱讀》由會(huì)員分享，可在線閱讀，更多相關(guān)《特質(zhì)焦慮對(duì)酒精依賴患者的抑制控制的影響：同時(shí)獲取ERPS和BOLD反應(yīng)2008已閱讀（43頁(yè)珍藏版）》請(qǐng)?jiān)谘b配圖網(wǎng)上搜索。

1、,單擊此處編輯母版標(biāo)題樣式,單擊此處編輯母版文本樣式,第二級(jí),第三級(jí),第四級(jí),第五級(jí),2015/4/20 Monday,#,Influence of trait anxiety on inhibitory control in alcohol dependent patients:Simultaneous acquisition of ERPs and BOLD responses,特質(zhì)焦慮對(duì)酒精依賴患者的抑制控制的影響：同時(shí)獲取,ERPS,和,BOLD,反應(yīng),Journal of Psychiatric Research,精神病學(xué)研究,2008,Impact Factor:4.092,Ger

2、many,一、問題提出（,Objectives,）,1,、,Alcohol-dependent patients often show various comorbid psychiatric symptoms.However,，,there is hardly any study considering the influence of these symptoms on cognitive processes,。,酒精依賴患者經(jīng)常會(huì)出現(xiàn)各種伴發(fā)精神疾病癥狀。但是，目前幾乎沒有任何研究來考慮這些癥狀對(duì)認(rèn)知功能的影響,。,直接說明自己研究主題，因?yàn)闆]人研究,。,2,、,There is som

3、e evidence that alcoholism may be associated with a range of cognitive and deficient behavioral control,。,目前已經(jīng)存在一些證據(jù)表明酗酒和一定范圍的認(rèn)知和行為控制缺陷有關(guān),。,但是還是存在一些相關(guān)研究表明我研究的問題還是存在的,3,、,No consensus exists about how different cognitive dimensions might be affected and whether there is a general decline in cognitive

4、 functioning or circumscribed impairments,。,關(guān)于不同的維度的認(rèn)知可能會(huì)受到影響，這一點(diǎn)并未達(dá)成一致。是否是認(rèn)知功能的普通降低或者說是限制性的損傷,。,有很多認(rèn)知功能，他們具體情況到底怎么樣還不明確，所以我要探討,4,、,Some studies,suggested that abilities which are mainly associated with right hemispheric functions are primarily affected in patients with alcohol use disorder,有些研究表明認(rèn)知

5、能力的損傷和右半球功能受到主要影響，對(duì)于酒精使用障。,表明自己為什么要用,FMRI,5,、,The go/nogo paradigmhas been widely used to show the neural correlates of response activation and inhibition and to assess impulsivity and control processes in healthy subjects,as well as several clinical groups,go/nogo,范式被廣泛的用于顯示健康者的反應(yīng)活動(dòng)和抑制的神經(jīng)關(guān)系，和用于評(píng)估沖動(dòng)

6、性和控制加工。也同樣用于一些臨床群體,。,我要用的范式是有效的,。,6,、,In contrast to event-related potentials functional MRI of the blood oxygenation level-dependent(BOLD)response measures hemodynamic changes in the brain associated with cognitive processes with a high-spatial resolution.,相比,ERP,，依賴血氧水平測(cè)量和認(rèn)識(shí)加工相關(guān)的大腦血氧變化的,FMRI,具有更高的

7、空間分辨率,。,為什么要用,FMRI,7,、,Epidemiological studies revealed that anxiety frequently co-occurs with alcohol use disorder,。,流行病學(xué)研究表明焦慮頻率和酒精使用障礙存在關(guān)系,。,表明我要研究的一個(gè)問題,。,二、研究假設(shè)（,Research hypothesis,）,The purpose of the present study was to examine the neural correlates of behavioral inhibition in patients suffe

8、ring from alcohol disorder and in healthy controls,and to determine the influence of anxiety on these processes,當(dāng)前研究的目的是為了檢驗(yàn)酒精障礙和健康控制組的行為抑制的神經(jīng)關(guān)聯(lián)問題和探究焦慮對(duì)這些加工的影響。,We assumed that patients suffering from alcohol disorder would show reduced nogo-P3 amplitudes and smaller inhibition-related BOLD response

9、s compared to healthy subjects.However,in alcohol-dependent patients with high-trait anxiety neural responses were expected to be more distinct,。,研究假設(shè)：,（,1,）酒精障礙患者和健康控制組相比表現(xiàn)出,nogo-P3,波幅減少和更小的抑制相關(guān)的,BOLD,反應(yīng)。,（,2,）高特質(zhì)焦慮的酒精依賴患者的神經(jīng)反應(yīng)存在更大差異,。,三、,Materials and methods,（材料和方法,）,（一）,Subjects,（被試）,Sixteen det

10、oxified male alcoholics(ICD-10:F 10.2)participated in the study.All alcoholic patients were inpatients on a ward specialized for alcohol and drug-related disorders at the Department of Psychiatry and Psychotherapy,Ludwig-Maximilians-University of Munich.,此研究中被試為,16,名酒精依賴男性患者。所有的患者都為住院病人，住在為酒精和藥物相關(guān)障礙

11、準(zhǔn)備的病房里。地點(diǎn)在慕尼黑，路德維希,-,馬克西米利安大學(xué)的精神疾病和心理治療部。,Exclusion criteria were stroke,head trauma,anoxia,encephalitis,learning disability,polysubstance abuse,and comorbid neurological or psychiatric disorders including anxiety disorder disorder(except depression).,排除標(biāo)準(zhǔn)：,中風(fēng)，頭部創(chuàng)傷，缺氧癥，腦炎，無學(xué)習(xí)能力，多種藥物亂用，伴隨神經(jīng)癥或者精神疾病的包括

12、焦慮障礙（抑郁除外,）,Three patients received psychotropics:two were on antidepressive medication,the other patient on anticonvulsive drugs,。,In addition,，,one patient was on antihypertensive medication,and one received myotonolytic drugs,。,The results of the patients were compared to those of healthy control

13、s,。,三個(gè)患者使用精神藥物：,2,個(gè)是抗抑郁藥物，一個(gè)是鎮(zhèn)痙的的藥物。另外，一個(gè)用抗高血壓的藥物，一個(gè)獲得,myotonolytic,藥物?；颊吆驼？刂平M進(jìn)行比較,。,A standardized questionnaire was used to exclude neurologic and psychiatric disorder or hearing problems.Three patients and two healthy subjects who were supposed to participate in the study did not understand the

14、instructions of the go/nogo paradigm and consequently were not included in any analysis.,排除標(biāo)準(zhǔn)：,一個(gè)標(biāo)準(zhǔn)化的問卷用于排除神經(jīng)癥和精神障礙或者聽力問題。其中參與實(shí)驗(yàn)的三個(gè)患者和兩個(gè)健康被試由于沒有理解,go/nogo,指導(dǎo)語(yǔ)。在隨后的數(shù)據(jù)分析排除。,Patients and control subjects were matched for age and verbal intelligence(Schmidt and Metzler,1992).According to the modified ve

15、rsion of the Edinburgh Inventory of Handedness(Oldfield,1971),15 of the participating patients were right-handed,one left-handed.In the control group,14 healthy controls were right-handed,two left-handed.,匹配：,患者和控制組在年齡好言語(yǔ)智力進(jìn)行匹配。根據(jù)修改版本的愛丁堡利手問卷測(cè)量得到，,15,個(gè)參與實(shí)驗(yàn)的患者為右利手，一個(gè)為左利手。在控制組中,14,個(gè)額外右利手，,2,個(gè)左利手。,A wr

16、itten informed consent was obtained from each participant after procedures had been fully explained.The study was approved by the local ethical committee.The investigation was carried out in accordance with the Declaration of Helsinki.Each healthy volunteer was paid 25 for participating in the study.,在整個(gè)程序完全解釋后，讓被試簽訂知情同意書。此研究得到當(dāng)?shù)貍惱砦瘑T會(huì)的支持。,這個(gè)研究的實(shí)施符合,Helsinki,的規(guī)則。每個(gè)參與研究的健康志愿者將會(huì)獲得的,25,。,（二）,Experimental procedures:go/nogo paradigm,（實(shí)驗(yàn)程序，,go/nogo,范式）,（三）,Analysis of behavioral data and EEG,（行為和,EEG,